Depends on what you mean by a story problem. Do you mean a part of the story won't come together, or have you written your story into a problem your characters can't overcome. It's the difference between "this plot point doesn't feel natural and I can't make it feel natural" vs "there's no believable way for the character's to sovle this mystery/beat this villain". In both cases, my first step, if you can, back away from the problem. When it comes to story, it's rarely the part you're stuck at that's the problem, but something befoe you became stuck. If you can ignore it and continue, it probably wasn't that importannt in the first place. But generally, if a plot point isn't coming together, or even your prose or specific scene isn't coming together, it's something further back in the build up that's the problem. Either you haven't set it up right, or something about the characterisation feels wrong.
If it's a matter of there's no believable way for this plot to be solved in universe, you haven't set up the plot right and that's a fundemental issue you need to rework because ignoring it can cause some major issues later.
If it's just that something about it feels wrong and won't come together naturally, the sort of thing often described as character's not cooperating, that's usually your instincts telling you this doesn't match with your characterization or pacing and you need to rethink. Ignoring this instinct is how you get plots and characters who feel unnatural and dragged around by the plot rather than driven by it, more common in people who stick rigidly to an outline.
So, generally, some of the best advice I've ever heard, is when you're in a corner, reverse out of the corner. But do not ignore it, it will compound and snowball and get even worse later on, unless it's a very minor issue.