I read mostly in the speculative fiction genres - scifi, fantasy, magical realism, etc., - but I will try anything! If it's good, it doesn't matter what genre it's in. I'll read comics-as-journalism (I really recommend the work of Guy Delisle and Joe Sacco), I'll read autobiographical stuff, I'll read slice of life, I'll read mystery, etc.
The only genre I'm hesitant about is outright horror, but that's mostly because I'm a big ol' scaredy cat and it gives me nightmares.