I basically did a 'coming soon' because a small local comic convention popped up a few months away and I wanted to to just get out what I could for it, even though I just started. Was important for me to network and tell the world I exist. (A lot of good did indeed come out of it.)
Thing is though that it's a short story that was 100% written from end to end, so the only thing I could possibly look back upon and regret is the art and not the writing. I think if you've got the plot written from point A to B, it can work. Otherwise, absolutely not. You could be spending hours drawing huge mistakes. Just be honest and forthcoming about it. First page of comic warns that there's no buffer and uploads on a monthly schedule. At the same time though, I'm not going to complain about lack of subs or anything. Doing it this way is definitely a slow grind but I also enjoy the luxury of taking it at my own pace and learning as much as I can as I go. I think it's important to decide what you want out of your comic and fully comprehend the pros and cons of each choice. It works for me because I'm in comics to learn how to do them - not necessarily to garner a huge audience. Your personal goals might align better with weekly uploads if you desire a large readership, however even then as your first comic, it's important to understand that it's going to be a slow burn.
Personally, I wouldn't use the cliffhanger as a factor to purposefully end on and wait for more uploads. I wouldn't rely on cliffhangers to really "hype" a comic that's brand new and people have no way of telling if you'll stick to it. It might just come off as slightly cruel. No matter which way you do it, you're just not going to have an audience that deeply cares until you have enough content to really pull them into the story. Depending on your pacing the amount of content you need varies greatly.