If I'm working for someone and getting paid to produce their idea, or if I'm contributing to group project then yeah, it's not going to be me that's making all of the decisions, (my involvement of course going to be different depending on the project). While for group projects, it's not going to be me that'll be making all the decisions.
For my webcomics which are done by me in every aspect, they are going to be what I want to do. The whole idea of me getting into webcomics in the first place was because I had the freedom to tell the story I want, and wasn't getting stopped with 'you can't do that' or 'you need more of this' or 'change that to that' and 'you need to change this because not enough people are going to relate or understand'
Of course when working on your own project, and this is true for both artists with lots of readers and artists trying to get readers, you're going to question what it is that people want or are expecting from you, as well as getting worried about turning people away / angering your readers if they react badly to the way you want to tell a story. After all, stories and comic fall under 'entertainment' and if people decide that you are not entertaining them in the way they would like they will leave.
Finding that fine line between entertainment and telling the story you want is difficult, for myself when balancing the two I will side with 'telling the story I want' for my own personal projects. If I wanted just to entertain someone and not worry about the direction, story and people deciding changes I would probably not be doing the enormous workload required to make a comic independently on my own.
It also helps to keep in mind that just because the story you want to tell may not be something the vast majority are interested in reading, it's very likely something someone in the minority would want to read or even NEED to read, and reaching out to them with stories they can enjoy is important as well.