Open-minded people. I think I target mostly people who are more sad than happy, since that's what my personal slice-of-life comic tends to lean toward. I hate it when overly optimistic/happy people overwhelm me with their cheery comments. I find those people to be insensitive and inconsiderate. If someone is normally happy but understands me when I say something really melancholy, then that's fine. That's them being understandable.
I feel like my sense of humor and the stuff I tend to talk about can get dark, morbid, and deep sometimes, so I expect my audience to be around the same age as me (16-17) or higher. Of course, age doesn't always correspond with maturity level, but that approximation is based on the assumption that it does.
I guess if you want to narrow it down, the audience I would never target are children. Like, ages 13 or lower. I don't want to be the one to ruin their innocence haha