Your title and description got me confused and it seems i'm not the only one, lol.
it honestly all depends on what we want out of making comics. if i'm financially stable (which i am, thankfully) then i'm cool to keep on working on my original ideas as they are even if they're not popular at all ( i'd still would LOVE to get an editor to help make my current script better ~the joys of writing in your second language~ :"D )
if i'm hoping to make this into a living, then the harsh reality is i just gotta suck it up and let more experienced people help make this into something better. (isn't that what editors are for, tho?)
But if you mean like... abandoning/have less time for my comic and get paid to work on something else (novel adaptation) then honestly i'm absolutely cool with that too. Heck, i'd even get extra creative with it more than what i do with my original comic since basically the script is already done and i don't have to worry about it or the damn dialogue anymore, lol.
TL;DR whichever pays best :")