AAA YES! I wanna get wacky! Real strange! Shit straight from the deepest reaches of my brain! I want stuff to happen that barely makes any sense at all! I want to draw all the weird stuff I can think of!
It's not necessary for a story to be completely cohesive to be enjoyable, but it may be hard for people to get into it if it's not. So you might need to start out simple, and gradually pull your audience into the bizarre story you had in mind. It really depends on what's most important to you when making a story, the audience, or the story you wanna tell.
But if you want to get weird with your story and experiment, I say go for it! All that matters is that you remember what's important to you and you're sure to get readers who genuinely like what you do.