In my current comic the main conflict is good vs evil, but i may focus on different types depending of the story i am telling.
Other types of conflicts that i find interesting, if written well, are conflicts with more than 2 sides. Those can be tricky to approach, specially with too many sides.
Blue vs Orange is kind of rare to see, because the good-evil and/or law-chaos axis are mostly explored.
The blue and orange morality is often saved for abominations, aliens, or excentric and/or crazy characters. They often serve as antagonists because of their actions.
2 sides fighting each other, each with a bizarre moral compass that doesn`t fit our morality system can be too weird and confusing. But just like any trope, if written well it can make something unique and fascinating.