Best advice I can gieve is to write about something that you know well. I mean lgbt is not even the top 10 popular genres... It may seems popular to you -cause you read it, search for it and targeting seo gives them to you on every media.
So If you are not lgbt yourself and you personally do not know such people, your story will be more of a guessing or cliche or retelling other stories which you like. SO aside of the fact thay your cast is lgbt - be sure to put them into compelling evironment and actuall story - with plot , with conflicts etc, I mean if you make a story about two school boys who bumped into each other in the toilet and suddenly dicided to have smexx it won't be fun , unless you draw it in a godlike style .
And if your story is good - the fact that it's lgbt won't be a problem - cause the stroy will drive your caraters and you will eventually develop them to fit in. You just need to figure out if them being lgbt actually matters to the plot. Otherwise you should try doing short strips or single art if you just want to draw pretty boys/girls kissing
Also figure out your target auditory - cause you know there are yaoi for the girls. and there is bara for actual gays. If you compare the themes and visuals you can guess the difference.