For me, it'd be a question of pacing. As a reader, if each 5-panel chunk has something happen in it that would be enough to feel like I really got an update on the situation, then twice a week would be cool!
But like, if a full page has kinda atmospheric pacing, to the point that you might have an entire 5-panel page of something like, "they approach a forest and then go cautiously into it," then splitting it up would make each update feel unsubstantial -- I think it would actually feel like you're getting less comic, even though it's more updates. Plus, putting a couple of days in between each half-page changes the pace it's read at, which may or may not be good for your story!
I'd say, look at how you'd split up your pages, and really imagine reading those half-pages one at a time, and think about whether you would really feel like you got a satisfying update afterwards! If yes, go for it. If no, keep it weekly. That's what I would do!