nope, but I have exactly 1 character who breaks the fourth wall, but it's not for comedic reasons.
mainly because the fourth wall is an actual in world construct of this comic's reality.
though to be honest, I'm personally not a big fan of characters pointing out flaws in writing and not really doing anything with that flaw.
it's like pointing at an issue and not really doing anything to actually fix or play with it.
"oh look, the artist forgot to draw your sword 3 panels ago, isn't that funny?!"
this is not to say you can have a funny conclusion with this.
like, idk. what if a buff, intimidating and deadly skeleton enter screen, then the characters notice him and they immediately ridicule him for how is it even possible for a skeleton to have such a high strength stat, but instead of ending it there.
Skeleman: I have so much strength because I consume lots of milk, the calcium makes my bones thick
Warrior: no you cant do that.
Skeleman: wait what? yes I can!
Warrior: you can't drink milk, because you lack the organs needed to digest and process the nutrients in it. you're a skeleton.
Skeleman: Stunned
Warrior: you can't have strength because you lack body mass, why do you have a six-pack and biceps through your clothes? all you are is just a pile a bones.
Skeleman: his muscles slowly disappear NO STOP IT! MY MUSCLES! I CAN have muscles! it's because I drank Skelemama's milk, that's how I can drink it! Bone milk is compatible with Skeletons!
Warrior: guess what Skeleman? Skelemom is also a skeleton, she lacks breasts to lactate, and you can't even be born because she doesn't have a womb to even birth you, therefore you shouldn't even exist.
Skeleman: Begins fading out of existence NOOOOOooooooooo vanishes