Honestly, I have this fear in the back of my mind that I'll get blasted for my comic. x'D I've seen artists and writers get dragged just for transgressive work, not being progressive enough, making tiny mistakes, being adults generally making adult art/fiction, or not representing a minority in a way certain people want. (Usually people not even in that minority, or dumb kids with no life experience.)
It's messed up because these people trying to mind their own business get death threats, stalked, harassed and sometimes doxxed, which is absolutely illegal but most victims can't afford taking the issue to court. Plus it's hard to make a case out of online discourse, which is even harder to do if the person is considered a public figure.
Back to the question though, I don't really know what I'd do, it depends on the severity but I'm super smalltime so it would be easy to take me out if anyone tried to do some hardball stuff. There was a person on Twitter who was trying to get some Youtube drama folks to make a video about me, @ing them about how dangerous my comic is, while calling me a bigot and pedophile, but they were ignored from what I saw. (Haven't seen any videos or hate mobs yet, so I assume they weren't taken seriously.) I like to keep a low profile just for my own privacy, so there isn't a whole lot of incriminating stuff anyone can find on me... unless someone can find my many different usernames over the years, and somehow dig out crap from my teens, which stuff like that is totally possible if the person is skilled enough. Either way I'd probably either keep trying to do my thing, or ghost for a bit if the situation gets too out of hand.
What's extra gross is these totally unsupervised kids and unhinged adults using something someone said or did 10+ years ago, most likely when the victim was in a bad mental state or dangerous situation, acting like they're still like that even though it's not true. Even more messed up is the times when it works, and the person gets gang banged by a mob expecting an apology, but don't relent even if the person complies. Like, jesus dude! It was just an artist who said gay guys were hot when they were 14, not a staff member of the Fort Simpson Indian Residential School who contributed in the murder of thousands of indigenous kids.
Edit:
I kinda disagree. I believe call-outs in general are bad, most of the time they're children totally overblowing a small issue for the blood sport, misunderstanding/misusing law to claim someone is a criminal when they're not, or interfering in something that should be handled by the police. The latter usually resulting in the person abandoning/deleting their accounts, and never seeing justice because these dumb kids just attacked them rather than gathering evidence, guaranteeing that the person will be able to continue offending in the future. Call-outs are a terrible idea.