For Our Universe, I think either way would work out! Though, I feel it'd thrive more as a movie rather than a show. I do a lot of time skips for the comic itself, because the focus is less on the years they spent together and more on how they spent them. I've seen cosmic works in both live-action and animated, so I think the story would fair well in either form.
For My Demon Valentine, I see it more as a animated special. Mostly because I've kinda see how CGI can have its effect on demons, monsters, and stuff. All I can say is that Adonis would fair better in an animated show if you'd want to understand why Sandra's attracted to him. 
Only exception is if I somehow got the same CGI people who did the Predator and Alien franchises. Then maybe.