Like @snailienz, Cowboy Bebop just came to mind.
But for ideas
-> animal related. Often that type of works change human, but seldom animal parts (horse legs, bisons eyes...), or processes linked with animal (feeding, milking, reproducing, riding...)
-> apply potential effect of dna modification / transplants / cloning to western standard settings (so biological approach to adapt classics)...
I like sharing random thoughts on things I probably won’t do. Besides, ideas are just that, execution is crucial...