This varies for me as I learn stuff and try different techniques.
Clean linework is my enemy XD, I just find it difficult and unpleasant. But recently I did some stuff while trying out a looser/sketchier lining style and it was surprisingly way more enjoyable.
Coloring... I kinda like coloring things in a somewhat messy and painterly way on one layer... sometimes. I dislike using the fill bucket tool, it's so tedious and having to go back and fill little pixel gaps especially bugs me. And recently I've found that I usually like coloring in black and white better than coloring with actual...colors.
Overall, lining wins for me (for now at least).