I set up my files in Photoshop CS6, then move into Corel Painter for all my sketching, inking, and freehand text. Then I move back into Photoshop for coloring, shading, borders, text, and final layout. I also have some speech bubble resources I made in Illustrator to save me from going crazy from freehanding or just using circle bubbles.
I keep looking into CSP, but keep putting it off. If it gets down in price again, I'll probably get it. The more I see/hear about it, the more convenient it sounds, but I'd definitely need to be at point where I'd have the time to learn a new program and get into the swing of things. Maybe for my next project!