Well, the primary title, "Mallory Bash," is just the name of the main character because it was originally conceived of as an animated series. But the subtitle for the current season, "The Dreaming Tree Saga," is a reference to the macguffin of the story--an actual sentient tree with the mind of a child--and a reference to the inspiration for the story, which is the song The Dreaming Tree from Dave Matthews Band's album, Before These Crowded Streets.
It also happens to be the name of Matthews' wine brand, which has some significance in an episode where Dustin finds some strange fruit growing in the basement at his father's estate.
There are a lot of Easter eggs in the comic, including the character of Cyrus, who...well, is pretty much just Dave Matthews: