I feel like depending on what you start with first completely sets how the story is going to feel. My previous comic it was more centered around the lore of the world and the story itself. I had the story and character roles, and I developed characters to fit those roles, so that's entirely what they were. The characters now looking back to it feel secondary to me. I still like, developed them, but they were just so intertwined with important events in the story that it felt to me like the story motivated the characters, not the other way around. I also have a problem of world building and becoming lore obsessed that the story may become boring or hard to get into for just casual reading. We're introduced to a number of characters before being introduced to them as characters.
The comic I focus on now is extremely character focused. I first created it by just playing with the concept of two specific characters, designed them, and then made the story around them. It's a different experience, but I still have some elements of (overly complicated) world building in it, but it's not necessary to know EVERYTHING to understand the characters.
Though like, when you have your main set of characters and story, eventually you'll get both characters you need to make for the story, and characters that just kind of pop up on their own and completely change the story, and for me, for the better.
Also just a side note, I have a hard time just having oc's that don't get fitted into a story. I GOTTA have a story, even if I never share it.
(sorry this is lengthy i got excited ;n; )