Not really, but I certainly like them differently.
My main character irritates me, because we have very different personalities, and he's pretty immature. I still love him, but would probably not be able to spend much time with him IRL. But, I really like drawing him, he's probably the character I like drawing the most, although there may be a tie.
On the other hand, there's another important character that I hate drawing (to the point that he looks different in pretty much every new panel.. ), but I feel closer to him, because our personalities are clashing less.