Some friends and family read em-- most don't. I don't really ever expect em to. They're not typically the audience for my work and I don't really feel the need to push it on them. I do give my parents first editions of whatever books I have in print and they always ask in every phone call "So, what are you working on?" I think its more that they just want to be sure I'm working still and earning money not so much interested in the actual comics which is more than alright by me!
My significant other is also a full time cartoonist and we read all of each other's work. Usually in a kinda editing capacity before things go through an actual editor. Sometimes it's just punching up each other's jokes. I think we're probably each other's biggest fans. Or maybe we're just trapped together and its Stockholm syndrome!! 