Making comics is very integral to my life, and I'm very lucky to just be able to... go ?
I do thumbnails, so that makes the first page a little bit less daunting, I think.
I set up my thumbnail pages, get out the two pens I'm going to use, and sticky notes. I usually have an idea of what I want to show on each page, and I draw whatever works. If it's really not working, I plaster a sticky note over it and keep going until it feels right.
The clearer idea I have in my head for a project, the easier it comes out of my hands. Some shorts that I work on have wobbly beginnings, because I wasn't sure what I wanted. It helps to back away from it and then return to iterate in those cases.