Usaully I don't jump straight onto big paper without doing thumbnails, but some people do, some people don't. Thumbnails is just doing a very tiny, tiny version of your page, so you can figure out what the flow will be. It's small and non-committal, and a safe place to fail a couple of times before jumping onto the big page.
But if it's more that the possibilities seem overwhelming, sometimes it helps to look at templates for ideas, especially if you're still getting the hang of paneling. Like if you type into google "comic template" you get a bunch of good ideas that are simple to parse because it's just panels.
Also I find it really helpful to look at page inspiration, I actually keep a pinterest board of just really cool comic panel layouts because I dunno about you but sometimes the white page is really intimidating, and it helps to see how other people solved similar problems to see how I can relate that to what to do in my own pages. It also just helps me see what I personally Iike in a comic page when I see what I've collected all next to eachother, although the stuff I like are way more complicated than what I would ever do. Anyway I keep it here https://www.pinterest.com/RAJillustration/comic-panels/
Overall though, for me the biggest thing in getting going with comics is making a pipeline to follow, and when I have my pipeline, I follow it closely and it's the same pipeline whether I do digital or traditional. First I take my script and decide what parts go in what panel, and then put a rough estimate of where those panels will be on the page. Then, I take the dialogue and I place dialogue first with a very light pencil--because dialogue always takes up like 2x what I expect it will--especially when it's handwritten. Whenever I've done traditional comics the page space for words is pretty real.
Then, I make some stick figure gestures of where my characters are and how big they will be, and what the rough backgrounds will look like. Then I make my bubbles, because bubbles are also freakin huge always, (and then after that, I'll have to reposition all my people again because half of them are now behind bubbles) and then I'll make the gutters and stuff all pretty with a ruler--and then and only then do I actually start drawing for reals.
I don't actually do any inking until fairly late in the drawing.