Gotta agree- anything so long as it's not distracting.
Used to make a comic on clip studio with meticulous perspective and it looked good but stiff. Now I make a comic where I just couldn't care less, so long as the idea of space or a person being a person is there.
As for accurate anatomy, I try to make figures that feel real, but they have big hands and feet (and butts...) because I think that's hot and I'm a shameless being. Plenty of artists do that, the famous examples usually being most comic women.
There are totally accurate proportioned comics like traced poser comics, and I feel they end up totally emotionless and I don't enjoy looking at them.
Basically if your art isn't inhibiting how well your scenes can be read, just shamelessly make what you like.