My best piece of advice would be to pick a subject you really like, and use it as the basis of your story.
This will help prevent research from feeling like homework-- nothing will drag down your work on a sci-fi story like the pressure to spend 10,000 hours studying something you don't understand and don't really care about before you can even begin to write.
If you like birds, write about a race of alien bird people. If you like video games, make life on your spaceship resemble a video game. Use your imagination, and center your story around the areas of science that interest you.
Also, don't be afraid of sci-fi readers. ^^; We're not all armchair scientists just waiting to tear your work apart searching for logic holes and inconsistencies. On the contrary, if one only cares for sci-fi that is "perfect" and beyond reproach, one will find one's reading list to be incredibly short, and missing a lot of foundational works in the genre.
Sci-fi fans will actually forgive a lot, as long as it's clear that you care about the things you're writing about, and that you have something important that you want to say. Morals and philosophy are a big thing in this genre; the main difference between good and great sci-fi usually isn't scientific accuracy, it's the presence of an impactful message about people or society or life in general that readers can take away from it.