I am LC with my parents, so I didn't tell them when I started my comic. However, about a year in, they blew my phone up one morning because my dad saw some of the comics on Bored Panda and recognized the characters as me and my two dogs, so they wanted to verify that it was me.
...then they didn't say anything until the next time they saw more comics in Bored Panda, several months later.
Them knowing does not change how I create my comic. Also, the bloodline will likely end with me, so I have zero concerns about kids/grandkids.