Nice challenge. I accept, and have come up with:
Struggle
But why?
Because that's all Mimsy is doing. She's struggling to elevate her restaurant while struggling to regain her former celebrity status while struggling to figure out why she isn't happy even though she has everything she could hope for (she's rich, though she is being instructed not to splurge her cash at this time) while struggling with her loneliness because she has no real friends while struggling to be taken seriously by the adults who look down on her, which is almost everyone. And that's just her. We have a cast of other characters, though not all, who are just as equally struggling with their problems, which the comic will get to eventually.