I gave the comic a read on my break at work, so now that I'm home here's a quick review
Art:
Off to a nice start so far! I'll skip straight to some specific areas that I think could use some additional work/attention beyond the things that you've already identified (i.e. anatomy, etc.). The first area that could use some additional detail I think are your backgrounds and especially some of the outside landscapes. I'll start by saying that it's great that you're not shying away from them! Some people try to dodge the problem by not including many backgrounds at all, but on the contrary your comic has them sprinkled throughout in most panels which is an awesome start. Specifically what I think could help them improve is just additional detail added to various aspects. For example, the beginning and end of the prologue happen in this grassy hilly area, but it's just very basic and kind of bland. The hills are flawless curves with no texture, there's no additional things in the landscape besides grass and road, etc. Much like the other commenters suggesting using references for poses and anatomy, using references for backgrounds can be super helpful too hitting google to look up inspiration can be a huge asset. For example looking through some photos like these:
can start to give some ideas of other elements that can be added to spice it up (trees, rocks, fencing, animals, etc.) Similarly the interior scene could use a little definition as well. The scale and nature of the space almost reminds me of something like an airplane building facility:
Some ceiling trusses and perhaps exposed structure in the walls instead of being finished with sheet rock are a few small things that would add a lot of dimension and interest to the scene
And then something that really shows off the contrast is how detailed the car is in that scene, since it's a 3D model, vs. the rest of the scenery that you hand drew. Not to say everything has to be super duper detailed, especially if you're going for a simpler style, but the car definitely stands out. Something to think about.
THAT SAID I already see tons of improvement happening across all aspects of the art from Prologue 1 to Prologue 2. The shading improves a ton already, and I see some experimentation happening with the clouds in the sunset, blades of grass starting to pop up and texture the ground a little, etc I'd say just keep it up!
Story/Dialogue:
It's very early on so there's not much to say about the story itself, but here are my initial thoughts:
the introduction detracts from the experience more than it adds, I think. It reads like a promotional commercial or like monologue at the start of a cartoon rather than the actual start of the story. By the time I was done reading Prologue 2 I had already forgotten what the introduction was even about as I was far more interested in what was going on with Marty and Alice. I fully agree with @liann that the info presented there could probably all be woven into the story more effectively than as an info dump up front. The scene with Marty staring at the Eden poster in the lab curious about what it is could open up a dialogue with his parents in the coming episodes about what it is, for example. I would evaluate perhaps removing that episode so that people can get straight to the good stuff.
As far as the actual plot thus far, it's interesting enough so far but a few things stand out. as @rajillustration already pointed out, a lot of the details being presented seem random or arbitrary in a non-cohesive way. Having to walk specifically 32 miles, it taking 5 hours randomly, the family waiting outside for Marty for 2 hours... everything just seems kind of extreme and over the top for the sake of it. I'm not sure how much we the reader get from getting told these random tidbits. Each time I encountered these hyperbolic instances I just thought to myself "huh?" or "wtf no one's parent in their right mind would wait outside in the running car for that long without going in to fetch the kid especially when he's alone and in the parent's place of work" xD
Further I'm not sure if it's intentional, but none of the characters are particularly likeable yet, which makes for a bit of a rocky start. Marty's rude and over the top all the time, the parents are like... low-to-mid key abusive, and Jeff started out kind of enigmatic/alright but he's proven to be kind of a jerk in the car scene as well. Alice stands out as being kind of the voice of reason and character that I've been able to relate to the most. Like I feel her pain here xDDD
Nothing stands out as particularly jarring (besides the bizarre interaction with the parents in the first episode) but having most of the cast be hard-to-like jerks toward one another, especially in the first few episodes make it hard to relate to them and get invested. Much like the art though, this is something that I'm sure will improve with time as you get more and more experiences with writing stories and dialogue
Finally regarding this bit:
Frankly, I think you've got a long ways to go, but I would highly recommend you read through this thread for some tips and ideas for how to get there:
the user Cabbage in particular is a Featured/Originals artist on Webtoon and spent a lot of time going through different people's comics and giving feedback and tips on the things that they could improve upon in order for a better chance at getting featured. While they haven't reviewed any new comics in a while (presumably due to being busy with their own), I would highly recommend reading their replies and applying as many of those tips as possible- as most of them are applicable to pretty much any comic
This ended up longer than expected but I hope it was useful