Well, I would hope so, I'm writing one.
Though out of the stories I've read, I think I've only read one, Adventures of a Traveling Fisherman by Keraca808 on Wattpad. (I recommend it. It has a really nice, easy-going vibe to it as the main character travels around meeting new faces.)
So I don't have the most experience actually reading the genre, but I've noticed things that make it work that also make me confident in my own writing.
In slice of life, characters are key. Recurring? One-off? Whatever. You gotta have standout characters, characters that the audience will want to see in situations.
The characters do not have to change, but it's probably easier to hold a reader's interest if some do. Slice-of-life gag comedies where every character stays stagnant are probably harder to translate to written form. But if your characters change over time? Congratulations, that is your plot.
It doesn't have to be the main characters. In fact, in the story I mentioned above, the main character doesn't really change all that much. He's kind of mysterious. It's the characters he meets on his journey that changes through meeting him, and it's often done in such a heartfelt or fun way that it made me interested in seeing how he affects the next person.
My writing tends to have characters going through a bunch of arcs, affecting each other's development along the way. That's an option, too.
I've always kind of resented the idea that a story must have a big conflict to work. Though, this is just my take.
Oh, I have that laying around my house somewhere. I should read it.