I think using CGI can be challenging, and it's certainly a less traveled path for comics, but it can still be very effective. And using 3D elements really isn't any less work if you're trying to come out with a finished product that looks good. For example, Atonement uses a blend of 3D and 2D elements. It's a very time consuming process, but it's allowed us to create a very unique art style that represents the spirit of the story well.
For example:
On the first page, you can see a blend of painted backgrounds (and background characters and objects) mixed with CGI renderings in the foreground that have been painted over.
On a later page ...
Again, you can see how our comic is blending CGI and painted elements to create a unique style.
There are so many different ways to draw comics. In any style, the quality is going to vary based on skill, experience, and effort.
To sidestep and talk about films for a second, there are a lot of people who prefer CGI to hand-drawn cartoons, or vice-versa. For me? I'd be hard-pressed to choose between Finding Nemo and Lion King. They're both fantastic, and those art styles were absolutely the best choices for those stories ... in my opinion, at least.