Well I got busy with life too, but I often find myself deciding against writing advice or giving my opinion here because I just don't have the energy to deal with the potential backlash; I need that energy for other stuff most of the time.
As for audience distancing, I do still add little authors notes on my updates to give people a small idea of what's on my mind or what's going on in life. I avoid letting it be too personal these days unless it touches on a topic that may be relevant to reader's lives. For example I may talk of experiences with dysphoria, discrimination and spiritual/paranormal stuff (all within the realm of the things I also write about) - but I won't tell people about family drama nor go into details about my romantic life.
As for responding to reader comments... I wouldn't have time for anything else if I still did that actively. I used to be one of those people that thought creators who didn't reply to comments were just cold, but having experienced an overflowing inbox firsthand... there's only so much time in the day and I have a life outside of my work!! I do read comments on my most recent update and reply once in a while if I have something to say. But that's as far as I can go.
Being too active with your fanbase when you're at a certain level can actually be dangerous. Being an online business, webcomic artists are already at higher risk of people with certain obsessive personality traits thinking they have an intimate relationship with you. This can turn volatile, just look up a few stalker cases and you will know what the development can look like.
I have a friend who ran into a very weird situation with a person, not quite stalker level but still obsessive and toxic. The person asked to be their friend, spammed them with messages, got angry when they didn't reply "fast enough" and would get very agressive when things didn't go their way. As for myself, I was sexually harrassed by a dude for 3 months straight, and someone once went apeshit in the comments all over my comic because I politely said no when they asked me to date them...