Luckily if there's things people hate about my comic, I don't hear about it too often. XP
Sometimes people don't care much for my art style, even if they still read the comic.
I've also had some people say they don't care much for the more squicky moments, but again, they stick around to read anyway! XD ....well, MOST of the time, I think I may have lost a few readers due to the violence.
Also, sometimes people act like it's a bad thing to dislike the main character (Daniel), like by saying that I'm going to be offended and try to defend him, but heck naw! I mean, sure, it's cool to like him purely as an entertaining character (or for the character he used to be), but you don't have to like him as a person-....err, vampire, or certainly not like his actions. Actually, at this point in the story especially, it makes perfect sense for readers not to like him!
I also used to have people suggest that my comic is too predictable, but...haven't heard this one for a while?