Weird, but I'd actually like to see more laid back sex related comedy comics? Like Oglaf. (NSFW) I feel like there's a lot of untapped potential for awkward situations relating to people trying to get laid. Also funny, consensual sex stuff is just very cute to me for some reason.
This would be nice too. I have a comic dealing with topics like suicide, abuse, and such, but it's definitely in the very unpopular/niche category. It would be nice for more people tackle darker, more sensitive topics. When done right they have a lot of potential to make great deeper works, and tap into a larger array of human emotion and character... depending on what kind of story you want to make.
(Great, now I really want to read JtHM again.)