I don't know about my favorite but I was surprisingly impressed with this non-comedic line from Dragon Ball Z: Abridged:
PERFECT CELL: I'm impressed! Behind all that angst and ridiculous hair, there's a real fighter!
TRUNKS: And behind all that insufferable smarm is a dead man!
PERFECT CELL: Trunks...you couldn't fathom the amount of dead men behind me.