I started my comic over multiple times, but I only recommend that as a last resort, and only if there are drastic changes to justify it, or if it needed to be redone to be published in print. If starting over, it should be done with the understanding of why it's being done, and how to make sure it doesn't need to happen again.
Starting all over for minor changes to the story wouldn't be worth all the time lost catching up again. Significant changes can also be made without starting over. If a comic shifts in genre from what was originally planned, it doesn't need to start all over, neither if a few retcons need to be made. These changes can be made smoothly.
When I restarted my comic and scrapped it again, I was sort of stuck in that redo loop because I could never feel satisfied, but there came a point where I knew to move forward.
The final rewrite for it started a few years ago. I was reluctant to start over, but I did as a last resort because of previous issues with the pacing and continuity, and the extent of those issues which I couldn't fix any other way. There were a lot of changes to the lore, characters, etc. I made while working on the previous rewrite, but retconning all of them in would've been very messy, and would've worsened the pacing problems. I tried to fix them, but it would've been smoother to start over, and have all of those additions and changes there from the beginning.
I made sure I wouldn't make the same mistake by more carefully planning out the final rewrite by establishing as much as I could about the lore, characters, the setting, the rules of the comic universe before I began making the pages for the reboot.