Assuming you're asking about a direction to take your work in:
The public doesn't know much but it does know what it likes. And people want what they like over and over and over and over and over and over and over... until they suddenly don't.
You want to make money off of comics? Draw what people like. Make a Shojou style princess comic, a Tumblr-style BL comic, or make Korean style modern romance. Something that looks like something they saw on TikTok. When they stop liking that, move on to the next thing.
What the public likes is pretty limited and thus easy to know what to ape.
And if you're asking in general: Everything above is still true. It's best to do what's popular. Always has been that way in every form of entertainment to come down the pipe.