Hi everyone,
Thanks for the replies. Yes, my main concern with this issue are for the bright saturated colors for web view, as they lose their vibrancy when converted to CMYK, since I do have plans to print the comic on paper when I'm done with it.
Actually, I've also done a testing today, the comic I'm posting here was all done in RGB and still looks acceptable on paper, (almost no difference at all)... It isn't a huge problem that affects an entire piece, only for certain parts like "neony" stuff as cryoclaire above said.