I use Photoshop and a rubbish Wacom bamboo tablet! I take the script and roughly thumb the page layout, then as of recently, I just work digitally straight away. Here's my basic method:
1) Create the layout of the panels
2) Organise the panel folders
3) Do the rough sketches for each panel
4) Finalise and digitally ink on new layers
5) Add flat colours
6) Add a background so I can then pick out light sources
7) Apply shadow and lighting to characters
8) Add bubbles and text and done!
For various techniques I use, you can see tutorials in my other series 'Tasha Doodle Dumps' where I elaborate on Photoshop and drawing techniques
hope this all helps in some way!