I go to ACen (when I can), CAKE!, Anime Midwest and ConAltDelete. And even SoyCon sometimes. I and some other Tapastic people are making arrangements to attend Anime Midwest together next year, and a few of us will likely be meeting up again at CAKE! like we did last year .
What's Wizardworld and C2E2 like? I haven't attended those cons before. I've actually grown to like smaller cons like ConAltDelete just because it's more personable and isn't stifled by so many rules and crowds.