The Out-of-Context Game

[PotooGryphon]

AAAHHH!!! OAO
Oops Comic Adventure

[shazzbaa]

Runewriters is pretty heavily dependent on context, but uh, here's, this one

[TACOBERTO]

[tomatobird]

I think this one is my favorite so far

[kristintipping7]

Evil Witch Allie

[eschaefges]

This panel always made me smile:

[Vikiro_Hop]

Technology malfunctions in Self Defeat

[PaulDevers]

I realized that a lot of them could work. But I think this one might be one of the funner ones.
From Low-Tier Jane.

[DTSaranya]

I'll just drop this here as well.

[thatphilippekid]

From my comic Bad Stew.

[DTSaranya]

[WakaXO]

[Zanreo]

Oh, I have quite a few of these:

(oh god this one is so old and terrible but still an amusing panel)

[NickRowler]

[eslameldeeb]

from my comic Enkido, and i regret nothing

[doublethickcustard]

oh boy this entire topic is amazing, Im really glad to know everyone has entire comics to give context to everything they have put here O_O
Galdranorn and the Fury

Two Kings

[El_Psy_Congroo]

Hmm dunno, maybe this one:

[jono_thompson]

Here is a panel from Moments

[AliceHoffmannArt]

Here's one from Stuff That Totally Happened:

[StrangeVision]

Eh.