Humour me41 The main character, Charlie is a very sassy and strong girl.
Big Jo16 Definitely, although this comic is now in LINE Webtoons :/
Mine, Be Brave11, is about a girl who overpass a case of bullying, does that count? XDD
I feel bad, I can only think of two that haven't already been suggested (and they're not on tapastic):
'Damsels Don't Wear Glasses59' - A sort of modern fantasy about a buff chick named Lave who works as a piece keeper between supernatural and non-supernatural beings.
I like Lave because of her not very traditional, loud, sort of "dude-bro" personality. Also you don't see that many muscular chicks in media.
'Shattered Starlight22' - A magical girl comic about an ex-leader who loses her job and is reassigned to work at a cafe.
There isn't a whole lot to this one yet but like Lave, the main character. Farah Shaughnessy isn't a super girly female character. She's sort of grumpy, serious and rather straight forward, which is kinda nice.
Huh, there's sort of a trend with me liking non-girly chicks...
As always, Goodbye to Halos!24 I like it because it hits on the deep emotional connection between friends really powerfully while still being a sweet and optimistic comic. I think Fenic is strong because she cares for her friends, won't let others define her, and wants to show love to everyone, which is honestly the bravest thing in the world to do.
Try Oh My Ghost28 You might get enjoyed
Unfamiliar21 is about four young witches supporting each other, working to become better together. ;w;
My comic, “The Archer and the Squirrel” has a female lead, and I’d consider it a feminist work. This fairytale tells the story of Lark, a young woman and skilled archer, living in medieval England. When her family is in financial need, she travels to a nearby kingdom in hopes of collecting a reward offered for capturing a “magical” white squirrel. During her search, she comes to learn more about the kingdom’s secret workings and begins to question her values and goals. This is a lighthearted story, suitable for all ages and lgbtq.
www.archerandthesquirrelcomic.com15
My lead character is a badass warrior. If you like action, you may give it a try ^^
Read here36
Wow! So many responses! Thank you!
@ratique I already follow Burning Bright and I really like it! I starting reading Devil's Acres I'm looking forward to where it is going.
@MissMagicGirl I love how the women in spejs aren't all stereotypical body types.
@Mythos I'm subbed to this and about half way through it. Started reading it a month or so ago? The art is SO SO incredible!
@Greg_Dickson I'm going to check these out! thank you!
@indagold your comic has such a different look to it, interesting! I'll check it out. 
@Wishjacked Wafflefry looks interesting. I'm going to tab it and look into it.
@infectedbloodcomics Interesting, ironic that your title has to do with eye color, but its a black and white comic... thank you for the recommendation, I'm looking forward to reading it!
@joannekwan these are very good comics. I've glanced at some of them before, I'll have to go back again and take a real look.
@dynamic I follow livNPC. It's a good comic! I haven't read all the way through it, I'm at about 60% or so.
@CHMsketches I really like your story Be Brave. I'm also subbed to it. And girls standing up for bullying is very strong. In fact everything about your comic has an awesome message, good characters.
@Bloomer non tapastic comics are fine. I just wanted to include some comic names besides Mockingbird, Spidergwen and Wonderwoman, you know? Shattlered Light is AWESOME...
sigh... break is over, I'll come back to check out everyone else's replies.
Oh, the shame of it! I originally meant to color it, but then decided to focus on improving my line art first. My next comic will be in color, though Thanks for checking GES out, I hope it will be a pleasant surprise for you as it's been for others.
I'm going to be really cheeky and suggest my own comic, although I second loads of the comics mentioned here, especially Damsels Don't Wear Glasses, The Property of Hate and Unfamiliar. They're some of my favs.
My comic Breaking the Lore3 is set in early medieval England and the lead is an older woman called Estrith, a midwife who aquires a baby through magical means.
It's a story about the ups and downs of a relationship between a mother and daughter who are both fiercely independant. And magical axolotl creatures.
(It's also fairly short, and finished! So you can read it in one sitting.)
Ooh, oh, there's lotta good ones here!
I haven't caught up in a while (sorry!) but I remember I liked the protagonist in Demon House13 a lot. There's also a sexy demon and she isn't there for fanservice, all her actions are understandable to her character, and she's really well-written and, AH, A+.
Self-promo tho, my webcomic, Cosmic Fish6 has two female leads from different ranks (one is a planetary guardian, the other is a monster-kid everyone assumes will turn violent and can only survive by stealing and being rude) and how their lives start to cross more often and, eventually, a potential friendship begins to grow. There are other female characters but they haven't had the chance to really show off (yet ôvô)
Witchy14 is a high fantasy comic set in an asia-based world where your magic ability is determined by the length of your hair. Nyneve, an uncharacteristically powerless witch, is thrown in the deep end when the army comes to enlist witches into their army.
Witchy is a brilliantly unique concept, aesthetically reminiscent of LOTR and HP - with soft, naiive-style art that tells the story perfectly.
Nyneve is a very deeply developed character, with steady character development from the get-go. She's determined, smart, and a fighter, but is also given time to be vulnerable and upset. She has a clear balance of faults and strengths. Generally, she's a very interesting and likable lead in a brilliant story.
the Sisters8 is strong women out the wazoo - centring around a family of 3 Irish-American witches who, thanks to their absent (likely satanist) parents, attract magical trouble like bees to a flower. This comic takes a frank, funny, modern look at magic without any of the Hogwarts glitter - a lack of which it makes up for in cartoon gore. This comic is like Gravity Falls if it stopped trying to be for kids.
The sisters in this comic spend most of their time either blowing something up, beating something up, or getting into effed up magical deals. They're blunt, crude, and really? They're assholes. The writer gives these women space to be messed up and angry, and make mistakes - and also to go loco, kill a few trolls, and save the day. They get all the depth and fallibility as male leads, with all the gore and violence.
aaaand gonna add a sneaky plug for There was a War7, my comic, in which both leads are strong women. Balor and Cath are on opposites sides of a long, bloody, and confusing war, and their worlds collide when Balor is forced into indentured labour in her people's army, and Cath is taken prisoner as a working witch at the same keep. Together, they patch up holes in their histories and forge a new existence where they can both be themselves, entirely.
Both girls are complicated, flawed, resilient young women who fight through waves of traumatic setbacks for what's right, and for some kind of peace. They are given space to be wrong, to be angry, and to be happy in themselves.
First off, all the comics @Greg_Dickson suggested look great, it looks like I'm going to be adding a few more comics to my list 
(Also, thank you for including Neon Rabbit, as always your awesome Greg! 👍😆)
That being said, Don't Be A Hero ( https://tapastic.com/series/Dont-Be-A-Hero11 ) by @Greg_Dickson is also a great read with an awesome female lead, Gemini, a super hero slaying badass on a quest for vengeance! If you go give the comics banner a look, you'll see there will be a large female presence in the cast.
Paradise ( https://tapastic.com/series/Paradise8 ) A diverse cast with a great lady lead (who is CRAZY fun) and a strong-willed secondary female character. It's a very colorful comic with great action.
Pest Caravan ( https://tapastic.com/series/Pest-Caravan7 ) has an unusual but super lovable female lead, who is a tad shy and also a pangolin monster. ^v^
Nocturne is a vampire thriller, with a strong-willed, short-tempered gal who just doesn't want to get involved! ( https://tapastic.com/series/nocturne-comic4 )
Household SlimeMold ( https://tapastic.com/series/HouseholdSlimeMold6 ) is a fantasy with a cute female protagonist, Mildew! She is smart, resourceful and at this very moment fighting a gaint rat 
Pretzel 2 Meet U ( https://tapastic.com/series/pretzel6 ) another fantasy comic, this one about 2 retired adventurers who start up a bakery. It's comedy and adventure all in one.
I have more but I'll end it here for now as this is getting a little long. Happy readings!
I'm quite fond of @haleymewsome 's Unfamiliar7, but I see she's already mentioned it herself
If you want a literally - strong - female lead, you could check out ours. No-Good Heroes21
I think you should look up on Sanity Circus9 which has a strong female lead. She doesn't take any shit and is dead set to find out why things happens around her!
I am the artist of Whetstone10. I joined on this project because I loved the characters and story. I consider Tavia to be a strong female lead. After her life is turned upside down during a modern worldwide apocalypse, she is able to get back on her feet and seek vengeance against those responsible. As intense as she can be, she still has a compassionate, sensible side that makes her very human. The story is still being released so you will get to know more about her as time goes on. 
Don't Be A Hero4 by @Greg_Dickson has a pretty good one. Gemini is super badass.
Centralia 20503 also has a good one.
Usually, I would sneak in a plug of my own comic, but my female lead (Elena) is more snarky and sarcastic than strong... but if that's fine, it's called Friends or Lovers?2