I'd need to remember the lessons I learned when Homestuck was at peak popularity (I'm in a popular fandub and back in the mid 2010s things got wild) and make my private contact channels ALL "contacts only", because I don't want people trying to DM me through literally every possible channel every day, and that was one of the most annoying things to deal with.
I'd want to get myself some sort of a good legal advisor, and probably an accountant to help manage things, since unlike fan content, I'd actually be making money from it and needing to deal with people who want to license my content.
And I might need to consider moving house to somewhere harder to find or at least harder to get close to for safety. Prominent female gay creators tend to get a lot of death threats and doxxing and stuff, so that wouldn't be super-fun and I'd rather have good security.
I'd likely quit my day job and consider hiring one or more assistants to help speed up production, and I'd be able to consider other projects maybe.
Mostly I'd just roll with things. I don't really think this is a hugely likely scenario, but I've worked with other people's big IP before and have a modest audience, so naturally I've thought about it.