I'm very much open to changes to things like story structure to fit the medium. Like when you look at Attack on Titan, the reason the first season of the anime is so much better than the manga is that they were able to look at that whole first arc, then completely restructure it to have much better pacing, setup and payoff, as well as to create pleasingly complete-feeling episodes. Then after season one, the anime famously goes downhill, loses all direction and kind of meanders, and that's because it becomes a much more direct translation of the manga.
Maybe if somebody looks at my comic from a wider vantage once large chunks of it are done, they'll go "Oh, actually, this prologue would work better as a couple of flashbacks later and people watching this as an animated series will want to get to know the main protagonist as an adult first". Fair enough, I'm sure a more experienced writer or editor might have changes that'd be beneficial, so I'm open to hearing them out.
However.... IF a change that was requested really changed the message or some of the characters... then we'd maybe have a disagreement on our hands, depending on what the changes were and the thought process behind them. For example if somebody was like "Okay, it's an action series with a female lead.... hmmm, yeah we think she needs to be sexier. She should wear a sexy outfit with heels and cleavage. And we think she'd be more appealing if her personality was more like Harley Quinn, you know like edgy, making random jokes... yeah!" or my absolute nightmare scenario, "Yeeeah okay so we're trying to market this at a male 13-25 kind of audience and they really don't like this lesbian sjw character, Sarin. We think she should be more like... Rekki's rival for Urien's affection and jealous of her, and like... maybe more of a cute genki Japanese schoolgirl archetype." Yeah if something like that happened, It'd be hard not to be like "STUFF YOUR MONEY UP YOUR ARSE!"