I think one comic that I've made that hits close to home is an older one I have called An Eye For An Eye.
It has some pretty dark themes (forced prostitution, gang violence, and human trafficking). Some of it is based on the extensive research I've done on public housing and its inner conflicts and communities (both in high school and in college), but a lot of it had to do with my own personal relationship with my biological mother (or rather, the relationship I desired).
This story is less of a lecture on the horrors of public housing gone wrong and more about the inner struggle of someone who wants strength and change and their inner turmoil when they happen to get more than what they bargained for. I know I've been on the tail end of those emotions myself, and I can only imagine how many other people go through the same way.
The story hasn't been completed yet, but looking over the finished script, it is raw with violence (and a lot of that violence is emotionally driven), and it's raw with emotional trauma and the unhealthy habits my main character has used to cope with them.
I think it will hit too close to home, especially with people who've gone through similar circumstances of abuse, tattered relationships, and bottled up emotions. I'm one of those people myself. But for me, I think it's best to just have it out in the open. To let it be as raw as those moments a lot of us go through -- and maybe give the message of "hey...you're not alone in this"
Of course, I do give warnings before each chapter, and I heavily remind people to not continue to read if it becomes to much. It doesn't get outright explicitly horrible, but I still like to give warnings.