I personally wouldn't, because I'm confused by this formatting.
Why are the characters looking at me when they're talking to themselves? Why are they looking at me and not holding a phone when they're on the phone? I don't know it if was even necessary to show the face of the person on the other end of the call, especially when the character having a closed mouth doesn't get across "speaking".
It feels like you're trying to reinvent the wheel by breaking a bunch of design conventions of comics without there being an obvious reason to. Like having speech bubbles without tails, strings of speech bubbles from the same person without connecting them, or very large gaps between panels that flow horisontally. If you're determined to do this visual novel style presentation, I'd recommend at least having everything else about the presentation be as conventional and easy to get into as possible to reassure the audience.
I think a comic in this format could work if it was told in a way where the format of the characters talking at the audience as a sort of third person observer was part of the story to make it make sense. Homestuck is told with video-game-like sprites that can be reused and text logs for dialogue, and makes it work because it was a suggestion comic kind of taking place in a video game that affects the real world, and the characters are all separated and communicate through chat apps. Carmilla, the live action web series, was a story where the framing device was that it was a vlog, so the characters always speaking to the camera, or interacting in small rooms facing the camera made sense. Visual novels, everyone faces the player and emotes at the player because the player character is in the scene and being spoken to, and it's a limitation VN writers need to be creative with, always making sure there's a way to have the player observe and be told important stuff, and using CGs for scenes where that format can't work.
There are comics that reuse the same assets over and over, like Dinosaur Comics, Wondermark, Elf Only Inn, any sprite comic you can name, but a key thing about them is they tend to use character assets that are facing more to the side and looking in front of them, not out at the reader, so it can be easily made to look like they're talking to and looking at each other. A bunch of popular comics in a more conventional style reuse certain head poses and expressions a bunch without formatting their comic in a weird VN-like way, because there are a bunch of generic poses that get reused a lot in comics.
The whole point of a comic is that the art tells the story, so if your aim is to tell a story in a way where you can reuse a pool of premade assets, I'd recommend either coming up with a story where the characters always talking to a third person audience stand-in (like, it's a video log, or the reader is a person in the scene), or create assets more designed for the characters speaking to each other, so facing and looking to the side, and with symmetrical designs so they can be flipped to face wither way easily.