Always!
It is a good way to engage with readers as all of them (from desktop to app users) can see it unlike the wall announcement (only desktop and mobile user can see it). Although they might be ignoring it, it is worth trying!
You can also engage them by asking questions about the story (e.g. "Do you think MC will reject him?"), the character (e.g. "Which twin do you like better?"), the technical aspect (e.g. "Is it okay if I change my update to Wednesday?"), or simply remind them to support you (not in an obnoxious way of course, just tell them "If you like this series, consider liking/subscribing/supporting! Thank you!").
If you get more comment in your episode, it is more likely to be bumped in Popular or Trending and increase your series visibility.