So I think, in regards to working in a vertical scrolling format, this is very successful. You've got some great pacing with really tightly-packed fast-moving chaotic action sequences combined with some really serene slow-paced bits, and a nice way of building tension with the physical scrolling. So in that respect, mad props.
As for your spelling, the one thing that stood out is that it's Dante's Inferno, with Dante being possessive, while you've got it spelled Dantes Inferno, like Dante is plural.
The only thing that really confused me as a reader is how the female character knew that the place she landed in was a place called Dante's Inferno, because nothing let the reader know how she knew. Has she been there before, and that's how she knew? Has she just heard about it spoken of? Even including a line of dialogue like, "Not this place again... I've been here before! Dante's Inferno!" Or, "I've heard about this place... Please don't let it be what I think it is! Dante's Inferno!" That will give the reader a little more information so it's not as confusing.
It's also a little hard right off the bat to see how Meredith's story has anything to do with the hybrid's story, or vice versa. The portal goes to Earth (?) But Meredith isn't on Earth anymore? She's in Dante's Inferno, but hybrid man is in a place called Chiaroscuro. And I'm currently far more interested in what happened to Meredith, rather than broody pretty boy's contemplations of life, so as a reader, if I didn't get more Meredith or very strong suggestions of how the stories might cross over sooner rather than later, I might lose interest.
Those are just my initial thoughts, but overall I think it's a really great start! Honestly!