Teen Witch is a pretty amazing film, though it's important to remember -- and a lot of people don't point it out when using that clip -- that it was a comedy-fantasy, and not meant to be taken straight. In the context of the film, that's actually a pitch-perfect sequence, and it's a really fun film. Which may be a good point to make: a consistent tone really helps when doing comedy.
My favorite type of comedy is the joke I don't get for a couple of seconds, and then it settles in and it was devastatingly clever and becomes hilarious because it took a moment. Like @matsuyacreative said, I love comedy that makes me think, and I think a commentary on the world at large is usually something great in terms of comedy. I also enjoy absurdism. And I'm not above gutter humor at all, I think things about bodily functions generally unite people since we all have them. They can, however, be overused, and it's probably best not to rely on toilet humor solely.
Probably the most important thing I can say, all in all, is this: keep your comedic tone consistent. Don't start off with a light, silly situation where Susan has her skirt tucked into her pantyhose and then next week Dennis is murdered by a capybara as your punchline. Sometimes a juxtaposition or contrast can be just the thing a joke or commentary needs, but consistency in tone is important in humor. If people come to expect a certain tone, it might actually backfire horribly if you give them something too drastically different.
Oftentimes people look to comedy as a relief and an uplifter. A lot of people won't feel like they can trust something that betrays that expectation of consistency, and it might cost you readers. Mileage varies, of course! But that's my take on it. 
