Basically you want to keep all your lettering in the safe zone and most of your panels in that place as well. But if you want a panel to touch the edge of the page you would draw in the bleed zone. This is called "full bleed."
When a book is being printed, assembled, and cut it's not an exact science so you need a little wiggle room so that nothing important gets cut off and so that full bleed art actually goes all the way to the edge of the page.