People will find and sub to your comic no matter how niche it is. Of course, you've still got to put yourself out there and commit to a regular updating schedule, but with the swath of BL, slice of life gag comics, and whatever else is "popular" on the site and with Staff right now, I feel that its worth saying for those who want to forge their own path, but are afraid that they might get caught up in that vicious cycle of "amount of views/subs equals validation" or even wholeheartedly believe it themselves.
If your comic is consistent, people will know it exists.
If your comic is good, the right people will find it.
If your comic has value, the right people will stick around for the long haul.