Life of an Aspie is still very much in its infancy right now, but like most everyone else here in this thread so far, I would definitely want a multi season anime rather than a 2 hour movie. As for the specifics of the anime itself, due to the main character being American in a Japanese setting, she would definitely have to speak some English as with the rest of the cast as well in the sub. In the English dub, I would want authentic Japanese voice actors who speak English well for the Japanese characters.
As for the tone/art direction of the anime, LooA is a shoujo by default categorization, but at the same time isn't strictly a shoujo either. Susan is a big big nerd. Video games, manga, anime, the works. so I guess LooA would have stylistic elements of something like Scott Pilgrim for example whenever a pop culture reference is made (or we see things through Susan's unique Asperger's fueled imaginative perspective.)